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1-Substituted 4-[Chloropyrazolyl][1,2,4]triazolo[4,3-a]quinoxalines: Synthesis and Structure-Activity Relationships of a New Class of Benzodiazepine and Adenosine Receptor Ligands

✍ Scribed by Barbara Matuszczak; Elšbieta Pekala; Christa E. Müller


Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
101 KB
Volume
331
Category
Article
ISSN
0365-6233

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Tricyclic Heteroaromatic Systems. 1,2,4-
✍ Vittoria Colotta; Daniela Catarzi; Flavia Varano; Lucia Cecchi; Guido Filacchion 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 416 KB

## Abstract Some 1,2,4‐triazolo[4,3‐__a__]quinoxalines 1–10, and 1,2,4‐triazino[4,3‐__a__]quinoxalines 11–12 were prepared and biologically evaluated for their binding at the benzodiazepine receptor (BZR) in rat cortical membranes. The BZR affinity of 1–10 demonstrates that the presence of a proton