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4-Substituted 1,5-Diarylpyrazole, Analogues of Celecoxib: Synthesis and Preliminary Evaluation of Biological Properties.

โœ Scribed by Giulia Menozzi; Luisa Merello; Paolo Fossa; Luisa Mosti; Antonietta Piana; Francesca Mattioli


Publisher
John Wiley and Sons
Year
2004
Weight
75 KB
Volume
35
Category
Article
ISSN
0931-7597

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โœฆ Synopsis


Abstract

For Abstract see ChemInform Abstract in Full Text.


๐Ÿ“œ SIMILAR VOLUMES


ChemInform Abstract: Synthesis and Biolo
โœ T. D. PENNING; J. J. TALLAY; S. R. BERTENSHAW; J. S. CARTER; P. W. COLLINS; S. D ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 35 KB

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-(5-(4-Methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl)benzenesulfonamide (SC-58635, Celecoxib). -Claisen condensation, followed by regioselective reaction with the hydrochloride