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4-Nitrophenyl 4-morpholinylphosphonochloridate: A convenient reagent for the synthesis of ribonucleoside mono-, di- and tri-phosphates

✍ Scribed by J. A. J. den Hartog; J. H. van Boom

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 676 KB
Volume: 100
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19811000709

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✦ Synopsis

Abstract

The synthesis of the crystalline and easily accessible phosphorylating agent 4‐nitrophenyl 4‐morpholinylphosphonochloridate is reported. Its application to the preparation of 5′‐phosphorylated ribonucleosides (e.g. pA, ppA and pppA) as well as RNA fragments (e.g. pUpU and ppUpU) is demonstrated. Further, special attention is paid to the mild removal of the 4‐nitrophenyl group from fully protected phosphotriester intermediates.

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