4-Isocyano-2,2,6,6-tetramethylpiperidin- 1-oxyl: A Valuable Precursor for the Synthesis of New Nitroxides

✍ Scribed by Zakrzewski, Jerzy; Jezierska, Julia; Hupko, Jarosław

• Book ID: 120516562
• Publisher: American Chemical Society
• Year: 2004
• Tongue: English
• Weight: 63 KB
• Volume: 6
• Category: Article
• ISSN: 1523-7060
• DOI: 10.1021/ol036298q

✦ Synopsis

To enrich the limited set of isonitriles typically employed, 4-isocyano-2,2,6,6-teramethylpiperidin-1-oxyl (1) is proposed as an isonitrile bearing a nitroxyl moiety. Isocyanide 1 was used in some reactions characteristic of isonitriles. Isoselenocyanate, amides (products of Passerini and Ugi reactions), and tetrazole derivative were obtained. The EPR spectra of the urea derivative 5b and a product of an Ugi reaction 7 (both dinitroxides) were analyzed.