4-Amino-5-vinyl-3(2H)-pyridazdazinones and related compounds; synthesis and evaluation of antinociceptive activity
✍ Scribed by Vittorio Dal Piaz; Claudia Vergelli; Maria Carla Castellana; Maria Paola Gioavannoni; Stefano Pieretti
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2002
- Tongue
- English
- Weight
- 221 KB
- Volume
- 39
- Category
- Article
- ISSN
- 0022-152X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract For Abstract see ChemInform Abstract in Full Text.
Several 4-nitro- and 4-amino-5-acyl-6-aryl-3(2H)pyridazinones were prepared and their in vitro and ex vivo antiaggregatory properties were evaluated. 4-Nitro derivatives 3 generally showed good activity in vitro towards arachidonic acid (AA)-induced human blood platelet aggregation. The 4-amino comp
## Abstract Ten new (5‐chloro‐2(3H)‐benzothiazolon‐3‐yl)propanamide derivatives have been synthesized. The compounds were tested for antinociceptive activity by tail clip, tail flick, hot plate and writhing test by using aspirin and dipyrone as standards. Among these compounds, 1‐[3‐(5‐chloro‐2(3H)
## Abstract Eight new 2‐methyl‐4(3__H__)‐quinazolinones **(8a‐8d, 9c, 9d, 10c, 10d)** with one or two chlorine atoms in the benzene ring and a 5‐methyl‐1,3‐thiazol‐2‐yl, 4‐methyl‐1,3‐thiazol‐2‐yl, and 5‐ethyl‐1,3,4‐thiadiazol‐2‐yl substituent in position 3 of the heterocyclic ring were synthesized