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4-Amino-3(2H)-pyridazinones Bearing Arylpiperazinylalkyl Groups and Related Compounds: Synthesis and Antinociceptive Activity.

โœ Scribed by Vittorio Dal Piaz; Claudia Vergelli; Maria Paola Giovannoni; Mark A. Scheideler; Giuseppe Petrone; Paola Zaratin

Publisher
John Wiley and Sons
Year
2004
Weight
185 KB
Volume
35
Category
Article
ISSN
0931-7597

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โœฆ Synopsis

Abstract

For Abstract see ChemInform Abstract in Full Text.

๐Ÿ“œ SIMILAR VOLUMES

5-Acyl-6-Aryl-4-Nitro-3(2HH)Pyridazinone
5-Acyl-6-Aryl-4-Nitro-3(2HH)Pyridazinones and related 4-amino compounds: Synthesis and pharmacological evaluation
โœ Vittorio Dal Piaz; Giovanna Ciciani; Giovanni Turco; Maria Paola Giovannoni; Mau ๐Ÿ“‚ Article ๐Ÿ“… 1991 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 772 KB

Several 4-nitro- and 4-amino-5-acyl-6-aryl-3(2H)pyridazinones were prepared and their in vitro and ex vivo antiaggregatory properties were evaluated. 4-Nitro derivatives 3 generally showed good activity in vitro towards arachidonic acid (AA)-induced human blood platelet aggregation. The 4-amino comp