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3p involvement in a renal cell carcinoma in von Hippel-Lindau syndrome: Region of tumor breakpoint clustering on 3p?

✍ Scribed by Hans-Joachim H. Decker; Hartmut P.H. Neumann; Thomas A. Walter; Avery A. Sandberg


Book ID
119103785
Publisher
Elsevier Science
Year
1988
Tongue
English
Weight
723 KB
Volume
33
Category
Article
ISSN
0165-4608

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Our previous cytogenetic and microsatellite analyses showed a terminal deletion of chromosome 3p segments with a breakpoint region between 3plI.2 and 3~14.1 bands in 98% of non-papillary renal cell carcinomas (RCC). This breakpoint region covers approx. 20-25 cM genetic distance. Earlier, we found a