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Loss of heterozygosity on 3p in a renal cell carcinoma in von Hippel-Lindau syndrome

โœ Scribed by Hans Joachim H. Decker; Robert M. Gemmill; Hartmut P.H. Neumann; Thomas A. Walter; Avery A. Sandberg

Book ID
119104204
Publisher
Elsevier Science
Year
1989
Tongue
English
Weight
286 KB
Volume
39
Category
Article
ISSN
0165-4608

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We report the case of a 26-year-old man with von Hippel-Lindau syndrome (VHL) and two renal cell carcinomas (RCC), one of which was studied cytogenetically. Chromosomal analysis of the RCC showed a translocation that involved chromosomes 3 and 8 with subsequent loss of the derivative chromosome 8. T