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[3H]muscimol binding in the rat retina

✍ Scribed by James M. Schaeffer


Book ID
118939876
Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
268 KB
Volume
27
Category
Article
ISSN
0024-3205

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## Abstract Bovine and rabbit retina synaptosomal fractions bind the potent and specific GABA agonist, [^3^H]‐muscimol with high affinity and limited capacity. The high degree of pharmacological specificity and the subcellular distribution of these binidng sites are similar to those reported for [^

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Autoradiographic studies were conducted on the binding of 3H-GABA and 3H-muscimol in cultures of rat cerebellum. Binding sites for both substances were observed on many cerebellar neurones, such as Purkinje cells and interneurones, but not on glial cells. Binding of 3H-GABA and 3H-muscimol was inhib