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[3H]CGP 61594, the first photoaffinity ligand for the glycine site of NMDA receptors

✍ Scribed by Dietmar Benke; Michael Honer; Roland Heckendorn; Mario F. Pozza; Hans Allgeier; Christof Angst; Hanns Mohler


Book ID
117188218
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
168 KB
Volume
38
Category
Article
ISSN
0028-3908

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3-Hydroxy-quinolin-2-ones: Inhibitors of
✍ Sing-Yuen Sit; Frederick J. Ehrgott; Jinnian Gao; Nicholas A. Meanwell πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 294 KB

A series of substituted 3-hydroxy-quinolin-2-one derivatives 6 was synthesized and evaluated as inhibitors of [3H]-glycine and [3H]-AMPA binding to rat cortical membranes. These compounds were generally found to be more potent ligands for the NMDA-associated glycine binding site than the AMPA recept