3-hydroxy-benzo(a)pyrene (3-OH-B(a)P) and mutagenic activity in rat urine were determined after the oral administration of benzo(a)pyrene given in three repeated doses of 10, 20 and 50 pmol kg-'. The procedure for the determination of 3-OH-B(a)P consisted of enzymic hydrolysis, separation and HPLC-a
[3H]benzo[a]pyrene utilization in rats following tracheal implant exposure
β Scribed by A.C. Marchok; G.S. Fleming; B.A. Tomkins; W.H. Griest
- Book ID
- 107937691
- Publisher
- Elsevier Science
- Year
- 1989
- Tongue
- English
- Weight
- 961 KB
- Volume
- 56
- Category
- Article
- ISSN
- 0300-483X
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The stability of the four benzojalpyrene-7,8,9,10-tetrahydrotetrols is investigated under hydrolysis conditions necessary to release the tetrols from haemoglobin. Two benzo[alpyrene (BP)-tetrols appeared to be rather stable under hydrolysis conditions, whereas two other BP-tetrols were unstable and