399 P53 serum antibodies in head and neck SCC
β Scribed by B. Roche; R. Lubin; S. Kolcielny; J. Bosq; B. Luboinski; F. Eschwege; T. Soussi; J. Bourhis
- Book ID
- 116167153
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 168 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0959-8049
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## Abstract ## Objectives This study aims at investigating the prognostic values of serum p53 protein and antiβp53 antibody in patients undergoing surgical treatment for head and neck squamous cell carcinoma (HNSCC). ## Methods Serum p53 protein and antiβp53 antibody concentrations were determin
The putative tumor suppressor gene p53 plays a key role in the regulation of cell proliferation. Functional loss of p53 protein through mutation or viral oncogene-complexing can result in p53 protein overexpression detectable by immunocytochemistry, which in turn has been associated with markers of