p53 serum antibodies as prognostic indicator in head and neck cancer
β Scribed by J. A. Werner; Stefan Gottschlich; Benedikt J. Folz; Tibor Goeroegh; Burkard M. Lippert; J.-D. Maass; Heinrich Rudert
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 87 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0340-7004
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## Abstract ## Objectives This study aims at investigating the prognostic values of serum p53 protein and antiβp53 antibody in patients undergoing surgical treatment for head and neck squamous cell carcinoma (HNSCC). ## Methods Serum p53 protein and antiβp53 antibody concentrations were determin
The putative tumor suppressor gene p53 plays a key role in the regulation of cell proliferation. Functional loss of p53 protein through mutation or viral oncogene-complexing can result in p53 protein overexpression detectable by immunocytochemistry, which in turn has been associated with markers of
## Background: Mutations of the p53 tumor-suppressor gene are common in squamous cell carcinoma of the head and neck (scchn) and may portend a worse prognosis. human papillomavirus (hpv) represents another potential prognostic factor for scchn. the oncogenic potential of hpv may be due to the abili
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