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39 In vivo overexpression of the cyclin-dependent kinase inhibitor p21WAF1/C1P1 in cutaneous malignant melanoma

✍ Scribed by Trotter, M.J.; Tang, L; Ho, V.C.; Tron, V.A.


Book ID
119174289
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
131 KB
Volume
12
Category
Article
ISSN
0923-1811

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WAF1/Cip1/Sdi1 (p21) is the prototype of a family of proteins that inhibit cyclin-dependent kinases and regulate cell cycle progression in eukaryotic cells. In addition to normal cell cycle progression, p21 is involved in growth suppression mediated by p53 and transforming growth factor beta (TGFbet