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384 Dicer1 is a synthetic lethal partner of tumour suppressor p53

✍ Scribed by D. Nittner; I. Lambertz; A. Schramm; P. Mestdagh; J. Vandesompele; M.A. Dyer; J. Schulte; J.C. Marine

Book ID
119602165
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
47 KB
Volume
8
Category
Article
ISSN
1359-6349

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## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasis‐associated gene __Nm23‐H1__, which encodes an 18‐kDa nucleoside diphos