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Is the KAI1 Metastasis Suppressor Gene a Cellular Target of p53? A Review of Current Evidence

✍ Scribed by Paul Jackson; Alain Puisieux


Book ID
115586879
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
44 KB
Volume
278
Category
Article
ISSN
0006-291X

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## Abstract __p53__, a tumor suppressor gene involved in the G1 cell cycle checkpoint, is also the most frequently mutated gene in human cancer. In addition, p53 modifies the ability of tumor cells to metastasize. The metastasis‐associated gene __Nm23‐H1__, which encodes an 18‐kDa nucleoside diphos