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377: Indoleamine 2,3-Dioxygenase in Lung Allograft Tollerance

✍ Scribed by F. Bini; S. Giuliano; P. Draghi; M. Pappalettera; A.M. Bardoni; R. Salvini; A.M. Fietta; F. Meloni

Book ID: 116521273
Publisher: Elsevier Science
Year: 2009
Tongue: English
Weight: 147 KB
Volume: 28
Category: Article
ISSN: 1557-3117
DOI: 10.1016/j.healun.2008.11.384

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## Abstract Human indoleamine 2,3‐dioxygenase (hIDO), a monomeric heme enzyme, catalyzes the oxidative degradation of L‐tryptophan (L‐Trp) and other indoleamine derivatives. Its activity follows typical Michaelis–Menten behavior only for L‐Trp concentrations up to 50 μM; a further increase in the c