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377 FUNCTIONAL ANALYSIS OF THE GROWTH AND DIFFERENTIATION FACTOR 5 REGULATORY POLYMORPHISM THAT IS ASSOCIATED WITH OSTEOARTHRITIS SUSCEPTIBILITY

✍ Scribed by R.J. Egli; L. Southam; J.M. Wilkins; I. Lorenzen; M. Pombo-Suarez; A. Gonzalez; A. Carr; K. Chapman; J. Loughlin


Book ID
114351588
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
43 KB
Volume
17
Category
Article
ISSN
1063-4584

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The growth differentiation factor 5 (GDF
✍ Aspasia Tsezou; Maria Satra; Pagona Oikonomou; Konstantinos Bargiotas; Konstanti πŸ“‚ Article πŸ“… 2008 πŸ› Elsevier Science 🌐 English βš– 94 KB

## Abstract Genetic factors have been shown to play an important role in the etiology of osteoarthritis (OA). A functional single nucleotide polymorphism (SNP) +104T/C; rs143383 in the 5β€² UTR of the GDF5 gene was recently associated with susceptibility to osteoarthritis in the Japanese and Chinese