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352 Involvement of Grb2 adaptor protein in nucleophosmin-anaplastic lymphoma kinase (NPM-ALK) mediated signaling and anaplastic large cell lymphoma growth

✍ Scribed by L. Riera; E. Lasorsa; C. Ambrogio; N. Surrenti; C. Voena; R. Chiarle

Book ID: 119603035
Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 43 KB
Volume: 8
Category: Article
ISSN: 1359-6349
DOI: 10.1016/s1359-6349(10)72059-0

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## Abstract The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPM‐ALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cel