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Inhibition of tyrosine kinase activity induces caspase-dependent apoptosis in anaplastic large cell lymphoma with NPM-ALK (p80) fusion protein

✍ Scribed by Melek Ergin; Mitchell F Denning; Keith F Izban; Hesham M Amin; Robert L Martinez; Shahnaz Saeed; Serhan Alkan

Book ID: 114216684
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 654 KB
Volume: 29
Category: Article
ISSN: 0301-472X
DOI: 10.1016/s0301-472x(01)00688-9

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## Abstract The t(2;5)(p23;q35) translocation results in the formation of a unique chimeric NPM‐ALK protein (p80). Expression of this protein is considered to be one of the clinical features of anaplastic large cell lymphoma (ALCL). Recently recognized as one clinical subtype of ALCL, the small cel