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35 - Germline mutations in the CDKN2 and CDK4 genes are rare in melanoma families in the UK

✍ Scribed by M. Harland; J.A. Newton Bishop; E. Pinney; V. Bataille; N. Spurr; J. Cuzick; Peter Selby; D.T. Bishop


Book ID
117664297
Publisher
Elsevier Science
Year
1997
Tongue
English
Weight
260 KB
Volume
33
Category
Article
ISSN
0959-8049

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The p16/CDKN2 (MTS1) gene encoding for the p16 inhibitor of cyclin D/CDK4 complexes is frequently mutated and deleted in a large fraction of melanoma cell lines, and p16 germline mutations have also been observed in familial melanomas. Moreover, a CDK4 gene mutation, responsible for a functional res