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A single nucleotide polymorphism in the 3′untranslated region of the CDKN2A gene is common in sporadic primary melanomas but mutations in the CDKN2B, CDKN2C, CDK4 and p53 genes are rare

✍ Scribed by Rajiv Kumar; Johanna Smeds; Petra Berggren; Oddbjørn Straume; Barbro Lundh Rozell; Lars A. Akslen; Kari Hemminki


Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
142 KB
Volume
95
Category
Article
ISSN
0020-7136

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Germline mutations within the CDKN2A gene, coding for the cyclin-dependent kinase inhibitor p16, have been detected by screening in 8% of Swedish families with an inheritance of cutaneous melanoma (FMM) and dysplastic nevus syndrome (DNS). Contrastingly, the closely related gene CDKN2B had no diseas