3.054 THE PREVALENCE OF CANCER IN PATIENTS WITH PARKINSON'S DISEASE WHO ARE CARRIERS OF THE G2019S MUTATION IN THE LRRK2 GENE
β Scribed by A. Mirelman; A. Thaler; T. Gurevich; A. Shkedy; A. Bar Shira; A. Orr-Urtreger; N. Giladi
- Book ID
- 117755157
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 60 KB
- Volume
- 18
- Category
- Article
- ISSN
- 1353-8020
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## Abstract Mutations in the LeucineβRich Repeat Kinase 2 gene (__LRRK2__) are mainly responsible for idiopathic Parkinson's disease (PD) with either a dominant pattern of transmission or a sporadic occurrence due to the reduced penetrance. A majority of __LRRK2__ kindreds demonstrate an extremely
To evaluate the frequency of the LRRK2 G2019S mutation in Italy, we tested 1,072 probands with Parkinson's disease (PD; 822 sporadic and 250 familial): 20 patients (1.9%) carried the G2019S mutation, 11 patients (1.3%) were sporadic, and 9 (4.3%) had a positive family history. Considering only proba