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3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of Highly Potent and Selective Metabotropic Glutamate Subtype 5 Receptor Antagonists.

✍ Scribed by Lida R. Tehrani; Nicholas D. Smith; Dehua Huang; Steve F. Poon; Jeffrey R. Roppe; Thomas Jon Seiders; Deborah F. Chapman; Janice Chung; Merryl Cramer; Nicholas D. P. Cosford


Publisher
John Wiley and Sons
Year
2006
Weight
9 KB
Volume
37
Category
Article
ISSN
0931-7597

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We have previously shown that (RS)-2-amino-3-[3-hydroxy-5-(2-methyl-2H-tetrazol-5-yl)isoxazol-4-yl]propionic acid (2-Me-Tet-AMPA) is a selective agonist at (RS)-2-amino-3-(3-hydroxy-5-methylisoxazol-4-yl)propionic acid (AMPA) receptors, markedly more potent than AMPA itself, whereas the isomeric com