3-Position modification of myo-inositol 1,4,5-trisphosphate: consequences for intracellular Ca2+ mobilisation and enzyme recognition
โ Scribed by Stephen T. Safrany; Robert A. Wilcox; Changsheng Liu; Barry V.L. Potter; Stefan R. Nahorski
- Book ID
- 113398327
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 776 KB
- Volume
- 226
- Category
- Article
- ISSN
- 0922-4106
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Partial benzoylation of the 3,4-dibenzyl ethers of D- and L-chiro-inositol provided the 1,2,5-tri-O-benzoyl-3,4-di-O-benzyl-chiro-inositols. Inversion of the free axial hydroxyl group gave a mixture of chiral 1,3,4- and 1,2,4-tri-O-benzoyl-5,6-di-O-benzyl-myo-inositols [W. Tegge and C. E. Ballou, Pr
The functional significance of the 2- and 3-hydroxyl groups of 1 D-myo-inositol 1,4,5-trisphosphate [Ins(1,4,5)P3] was probed by using Ins(1,4,5)P3 analogues variously modified at positions 2 and 3 or elsewhere. The intrinsic activities of these compounds were compared to that of Ins(1,4,5)P3, using