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3-deaza- and 7-deazapurines: duplex stability of oligonucleotides containing modified adenine or guanine bases

✍ Scribed by T. Grein; S. Lampe; K. Mersmann; H. Rosemeyer; H. Thomas; F. Seela


Book ID
108476970
Publisher
Elsevier Science
Year
1994
Tongue
English
Weight
499 KB
Volume
4
Category
Article
ISSN
0960-894X

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Oligonucleotides containing 7-substituted 8-aza-7-deazaguanines ( 6-amino-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-ones) were prepared by automated solid-phase synthesis. A series of 7-alkynylated 8aza-7-deaza-2'-deoxyguanosines (see 4a Β± d) were synthesized with the 7-iodonucleoside 3c as starting