Single-crystal X-ray study T = 296 K Mean (C-C) = 0.004 A Disorder in main residue R factor = 0.065 wR factor = 0.175 Data-to-parameter ratio = 16.3 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.
3-Carboxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide, new prodrug for the antiarthritic agent 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide
✍ Scribed by Patterson, John W.; Cheung, Paul S.; Ernest, Michael J.
- Book ID
- 120255728
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 463 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0022-2623
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📜 SIMILAR VOLUMES
The structure of the title compound, C 18 H 14 F 4 N 2 O 2 S, consists of molecules that pack in a linear hydrogen-bonded chain along the c axis. This hydrogen-bonding arrangement involves the hydroxy group and one of the sulfonyl O atoms.
The title compound, C 18 H 14 F 4 N 2 O 2 SÁCHCl 3 , forms a onedimensional hydrogen-bonded chain via a single O-HÁ Á ÁN interaction; the chain runs approximately along the [110] axis. The two benzene rings are almost parallel to one another, forming a dihedral angle of 8.43 (8) .
The title compound, C 26 H 17 ClF 5 N 3 O 5 , belongs to a new class of amide compounds having potential biological activity. The pyrimidine ring makes a dihedral angle of 61.66 (2) with the adjacent benzene ring. The dihedral angle between the other two benzene rings is 73.12 (1) . There are intram