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3-Carboxy-5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide, new prodrug for the antiarthritic agent 2-cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide

✍ Scribed by Patterson, John W.; Cheung, Paul S.; Ernest, Michael J.


Book ID
120255728
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
463 KB
Volume
35
Category
Article
ISSN
0022-2623

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📜 SIMILAR VOLUMES


N-[4-Cyano-3-(trifluoro­meth­yl)phen­yl]
✍ Hu, Xiu-Rong ;Wang, Li-Li ;Gu, Jian-Ming 📂 Article 📅 2006 🏛 International Union of Crystallography 🌐 English ⚖ 201 KB

Single-crystal X-ray study T = 296 K Mean (C-C) = 0.004 A Disorder in main residue R factor = 0.065 wR factor = 0.175 Data-to-parameter ratio = 16.3 For details of how these key indicators were automatically derived from the article, see http://journals.iucr.org/e.

N-[4-Cyano-3-(trifluoro­meth­yl)phen­yl]
✍ Hu, Xiu-Rong ;Gu, Jian-Ming 📂 Article 📅 2005 🏛 International Union of Crystallography 🌐 English ⚖ 254 KB

The structure of the title compound, C 18 H 14 F 4 N 2 O 2 S, consists of molecules that pack in a linear hydrogen-bonded chain along the c axis. This hydrogen-bonding arrangement involves the hydroxy group and one of the sulfonyl O atoms.

N-[4-Cyano-3-(trifluoro­methyl)phenyl]-3
✍ Tang, Gu-Ping ;Gu, Jian-Ming 📂 Article 📅 2005 🏛 International Union of Crystallography 🌐 English ⚖ 250 KB

The title compound, C 18 H 14 F 4 N 2 O 2 SÁCHCl 3 , forms a onedimensional hydrogen-bonded chain via a single O-HÁ Á ÁN interaction; the chain runs approximately along the [110] axis. The two benzene rings are almost parallel to one another, forming a dihedral angle of 8.43 (8) .

N-{2-Chloro-5-[3-methyl-2,6-dioxo-4-(tri
✍ Tian, Zhi-Gao 📂 Article 📅 2007 🏛 International Union of Crystallography 🌐 English ⚖ 340 KB

The title compound, C 26 H 17 ClF 5 N 3 O 5 , belongs to a new class of amide compounds having potential biological activity. The pyrimidine ring makes a dihedral angle of 61.66 (2) with the adjacent benzene ring. The dihedral angle between the other two benzene rings is 73.12 (1) . There are intram