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3- and 4-Pyridylalkyl Adamantanecarboxylates: Inhibitors of Human Cytochrome P45017α (17α-Hydroxylase/C17,20-Lyase). Potential Nonsteroidal Agents for the Treatment of Prostatic Cancer

✍ Scribed by Chan, Ferdinand C. Y.; Potter, Gerard A.; Barrie, S. Elaine; Haynes, Benjamin P.; Rowlands, Martin G.; Houghton, John; Jarman, Michael


Book ID
115456759
Publisher
American Chemical Society
Year
1996
Tongue
English
Weight
122 KB
Volume
39
Category
Article
ISSN
0022-2623

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## Background: The purpose of this study was to determine the effects of a nonsteroidal c17-20 lyase inhibitor, 2-(1h-imidazol-4-ylmethyl)-9h-carbazole (ym116), on serum concentrations of androgens and ventral prostatic weight in rats. ## Methods: Serum concentrations of testosterone and of dehyd