Active-site conformation of 17-(3-pyridy
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David F. Burke; Charles A. Laughton; Chris F. Snook; Stephen Neidle; Gerard A. P
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Article
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1995
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Elsevier Science
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English
⚖ 228 KB
17-(3-pyridyl)androsta-5,16-dien-3[~-ol, a nanomolar inhibitor of the P450 enzyme C17ct-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme.