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Active-site conformation of 17-(3-pyridyl)androsta-5,16-dien-3β-ol, a potent inhibitor of the P450 enzyme C17α-hydroxylase/C17-20 lyase

✍ Scribed by David F. Burke; Charles A. Laughton; Chris F. Snook; Stephen Neidle; Gerard A. Potter; Michael Jarman

Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 228 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00178-v

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✦ Synopsis

17-(3-pyridyl)androsta-5,16-dien-3[~-ol, a nanomolar inhibitor of the P450 enzyme C17ct-hydroxylase/C17-20 lyase, is a target for prostate cancer chemotherapy. A model is presented for the inhibitor docked into the structure of the enzyme.

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