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3-Aminoquinazolinones as chiral ligands in catalytic enantioselective diethylzinc and phenylacetylene addition to aldehydes

✍ Scribed by Karabuga, Semistan; Karakaya, Idris; Ulukanli, Sabri


Book ID
124108642
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
623 KB
Volume
25
Category
Article
ISSN
0957-4166

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Secondary amines react with (IR,2S)-indene oxide 1 in a completely regioselective manner leading to trans-2-dialkylamino-l-indanols 4a-d in high yield. A Mitsunobu inversion via the corresponding p-nitrobenzoates, followed by reduction with DIBALH leads to the cis-2-dialkylamino-l-indanols 5a-d also