## Abstract For Abstract see ChemInform Abstract in Full Text.
Enantioselective addition of diethylzinc to aldehydes using 1,4-aminoalcohols as chiral ligands
β Scribed by Dina Scarpi; Fabrizio Lo Galbo; Ernesto G. Occhiato; Antonio Guarna
- Book ID
- 108283751
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 295 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0957-4166
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π SIMILAR VOLUMES
## Abstract The new chiral Ξ²βaminoalcohols of indolinylmethanols (__1__) and their reduced derivatives (__2__) were synthesized from (__S__)βindolineβ2βcarboxylic acid. Both (__R__) and (__S__) enantiomers of the optically active secondary alcohols have been successfully obtained in high enantiomer
Secondary amines react with (IR,2S)-indene oxide 1 in a completely regioselective manner leading to trans-2-dialkylamino-l-indanols 4a-d in high yield. A Mitsunobu inversion via the corresponding p-nitrobenzoates, followed by reduction with DIBALH leads to the cis-2-dialkylamino-l-indanols 5a-d also