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3-Amino-4-hydroxybenzoic Acid: the Precursor of the C 7 N Unit in Asukamycin and Manumycin

✍ Scribed by Hu, Yiding; Melville, Chris R.; Gould, Steven J.; Floss, Heinz G.


Book ID
127263180
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
93 KB
Volume
119
Category
Article
ISSN
0002-7863

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The synthesis of 4-amino-3,4-dideoxy-o-arabino-heptulosonic acid 7-phosphate (15), the first committed intermediate in a new branch of the shikimate pathway of aromatic biosynthesis, is reported from 2-deoxy-D-glucose in 14 steps in lo-12% overall yield.