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The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review

โœ Scribed by Floss, Heinz G; Yu, Tin-Wein; Arakawa, Kenji


Book ID
109869145
Publisher
Nature Publishing Group
Year
2010
Tongue
English
Weight
742 KB
Volume
64
Category
Article
ISSN
0021-8820

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Synthesis of 4-amino 3,4-dideoxy-d-arabi
โœ Andreas Kirschning; Philippe Bergon; Jeh-Jeng Wang; Steven Breazeale; Heinz G. F ๐Ÿ“‚ Article ๐Ÿ“… 1994 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 956 KB

The synthesis of 4-amino-3,4-dideoxy-o-arabino-heptulosonic acid 7-phosphate (15), the first committed intermediate in a new branch of the shikimate pathway of aromatic biosynthesis, is reported from 2-deoxy-D-glucose in 14 steps in lo-12% overall yield.