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Formation of 3-amino-5-hydroxybenzoic acid, the precursor of mC7N units in ansamycin antibiotics, by a new variant of the shikimate pathway

✍ Scribed by Kim, C. G.; Kirschning, A.; Bergon, P.; Ahn, Y.; Wang, J. J.; Shibuya, M.; Floss, H. G.

Book ID
125960745
Publisher
American Chemical Society
Year
1992
Tongue
English
Weight
396 KB
Volume
114
Category
Article
ISSN
0002-7863

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✍ Andreas Kirschning; Philippe Bergon; Jeh-Jeng Wang; Steven Breazeale; Heinz G. F πŸ“‚ Article πŸ“… 1994 πŸ› Elsevier Science 🌐 English βš– 956 KB

The synthesis of 4-amino-3,4-dideoxy-o-arabino-heptulosonic acid 7-phosphate (15), the first committed intermediate in a new branch of the shikimate pathway of aromatic biosynthesis, is reported from 2-deoxy-D-glucose in 14 steps in lo-12% overall yield.