3-(4-Aminobutyn-1-yl)pyridines: binding at α4β2 nicotinic cholinergic receptors
✍ Scribed by Deniz Dogruer; Mase Lee; Malgorzata Dukat; M.Imad Damaj; Billy R. Martin; Richard A. Glennon
- Book ID
- 108073141
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 162 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0960-894X
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We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of a3and a6-containing nicotinic receptors. In particular, compound 17a from this series is a potent a3b4 and a6/4b4 receptor agonist in terms of both binding and functional activity. Compound 17a also show