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Radiosynthesis of the α4β2 nicotinic acetylcholine receptor ligand: 5-((1-[11C]-methyl-2-(S)-pyrrolidinyl)methoxy)-2-chloro-3-((E)-2-(2-fluoropyridin-4-yl)vinyl)pyridine

✍ Scribed by Hayden T. Ravert; Yi Zhang; Andrew Horti; Robert F. Dannals

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
86 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

5-((1-[

]-methyl iodide and the corresponding normethyl precursor. The average time of synthesis, purification, and formulation was 42 min with an average non-decay-corrected radiochemical yield of 19%. The average specific radioactivity was 359 GBq/mmol (9691 mCi/mmole) at end of synthesis (EOS).

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