We report the synthesis of a series of [3.2.1]azabicyclic biaryl ethers as selective agonists of a3and a6-containing nicotinic receptors. In particular, compound 17a from this series is a potent a3b4 and a6/4b4 receptor agonist in terms of both binding and functional activity. Compound 17a also show
Study of the calcium dynamics of the human α4β2, α3β4 and α1β1γδ nicotinic acetylcholine receptors
✍ Scribed by Sandra Michelmore; Kim Croskery; Joachim Nozulak; Daniel Hoyer; Rémy Longato; Anja Weber; Rochdi Bouhelal; Dominik Feuerbach
- Publisher
- Springer-Verlag
- Year
- 2002
- Tongue
- English
- Weight
- 177 KB
- Volume
- 366
- Category
- Article
- ISSN
- 0028-1298
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Neonicotinoids are synthetic, nicotine‐derived insecticides used for agricultural and household pest control. Though highly effective at activating insect nicotinic receptors, many neonicotinoids are also capable of directly activating and/or modulating the activation of vertebrate nico
BACKGROUND: CP-601927 is a selective a 4 b 2 nicotinic acetylcholine receptor (nAChR) partial agonist. The objective of this study was to assess the potential effects persisting into adulthood when CP-601,927 was administered to neonatal/ juvenile rats. Since the juvenile toxicity study was being pe