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296 POSTER Design, synthesis and evaluation of extended heterocycle linked C8/C8′ pyrrolo[2,1-c][1,4]benzodiazepine DNA cross-linking agents

✍ Scribed by P.W. Howard; A. Tiberghien; S.J. Gregson; G.-D. Kang; M. Stephenson; K. Kiakos; S. Klee; J.M. Hartley; J.A. Hartley; D.E. Thurston


Book ID
118623924
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
61 KB
Volume
4
Category
Article
ISSN
1359-6349

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✍ D. E. THURSTON; D. S. BOSE; A. S. THOMPSON; P. W. HOWARD; A. LEONI; S. J. CROKER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 38 KB 👁 1 views

Synthesis of Sequence-Selective C8-Linked Pyrrolo(2,1-c)(1,4) benzodiazepine DNA Interstrand Cross-Linking Agents. -In order to construct the key A-ring fragments (VI), a versatile convergent approach is developed to join two units of vanillic acid (I) with α,ω-dihaloalkanes (II). The "amino-thioac