## Abstract The chromosome region 8p12โp22 shows frequent allelic loss in a variety of human malignancies, including breast cancer (BC). The tumor necrosis factorโrelated apoptosisโinducing ligand (TRAIL)โreceptors TRAILโR1, โR2, โR3 and โR4 are located on 8p21โp22 and might be candidate tumor supp
271 Quantitative Analysis of RORalpha mRNA Expression in Human Breast Cancer
โ Scribed by H.O. Odawara; J.H. Horighchi; T.I. Iwasaki; N.R. Rokutanda; R.N. Nagaoka; H.T. Tokiniwa; A.S. Sato; Y.K. Koibuchi; N.K. Koibuchi; I.T. Takeyoshi
- Book ID
- 117662180
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 79 KB
- Volume
- 48
- Category
- Article
- ISSN
- 0959-8049
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We have carried out a quantitative analysis of ER-alpha and ER-beta mRNA expression in normal (n = 11) and breast cancer (n = 112) tissues using a real-time (Taq-Man) PCR assay. Expression of ER-beta mRNA variants has also been studied by triple-primer PCR assay. ER-alpha mRNA levels in normal breas
## Abstract ## Introduction The cyclooxygenaseโ2 (COXโ2), responsible for the conversion of arachidonic acid into prostaglandin (PG) E2, is known to increase intracellular cAMP and estrogen production in malignant breast tissue. The aromatase enzyme complex is responsible for local production of e
## Abstract The ADAMs (a disintegrin and metalloprotease) are membrane proteins containing both protease and adhesion domains and thus may be potentially important in cancer invasion and metastasis. The aim of our study was to investigate the distribution and potential clinical significance of ADAM