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266 GLUCOSAMINE SULFATE REDUCES THE PROSTAGLANDIN E2 PRODUCTION IN OSTEOARTHRITIC CARTILAGE THROUGH THE INHIBITION OF mPGES-1

✍ Scribed by M. Kapoor; F. Mineau; H. Fahmi; J.-P. Pelletier; J. Martel-Pelletier

Book ID: 114352648
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 124 KB
Volume: 19
Category: Article
ISSN: 1063-4584
DOI: 10.1016/s1063-4584(11)60293-8

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## Abstract ## Objective Microsomal prostaglandin E synthase 1 (mPGES‐1) is the final enzyme of the cascade that produces prostaglandin E~2~ (PGE~2~), a key actor in arthritis. To study mPGES‐1 synthesis in human cartilage and its regulation by interleukin‐1β (IL‐1β), we used human cartilage and a