2,4-Dimethoxybenzyl as a protecting group for glutamine and asparagine in peptide synthesis
β Scribed by Marshall, Garland R.; Pietta, P. G.; Cavallo, P.
- Book ID
- 121265857
- Publisher
- American Chemical Society
- Year
- 1971
- Tongue
- English
- Weight
- 739 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0022-3263
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π SIMILAR VOLUMES
## Abstract The title compounds have been prepared by a simple and economical procedure from the corresponding Bocprotected Ξ±βbenzyl esters and [^15^N]ammonia with N,Nβ²βcarbonyldiimidazole as coupling agent. Catalytic hydrogenolysis furnished both labelled products in high overall yields suitable f
A new hydroxy-protecting group for Ser, cyclohexyl, has been developed, and its application to the solid-phase peptide synthesis has been demonstrated successfully in combination with NΒ°t-Boc protection and the Merrifield resin support.