2′(3)′-O-l-(O-methyl-3-phenyllactyl) adenosine A potential analog of 2′(3′)-O-aminoacyl ribonucleosides
✍ Scribed by Jiří Žemlička; James Owens
- Book ID
- 115746320
- Publisher
- Elsevier Science
- Year
- 1976
- Weight
- 330 KB
- Volume
- 442
- Category
- Article
- ISSN
- 0005-2787
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The eeterificatlon of the hydroxyllc function in position8 2' or 3' of the terminal adenoslne unit of the soluble (tran8fer) ribonucleic acid by an emin acid repreeent8 an important step in the biosynth88is of proteins (1). Although no non-enzymatic method8 for the attechaent Of an miuOaCy1 residue
3'-a-Carboxymethyl-2"O-methyl ribonucleosides, which are important building blocks for the construction of high affinity amide modified antisense oligonucleotides, have been synthesized from the corresponding 2'-O-methyl ribonucleosides via catalytic hydrogenation of their 3'-deoxy 3'-methoxycarbony
2-C-Methylglyceraldehyde derivatives are among the simplest branchedchain chiral synthons and both the (R)-enantiomer and the (S)-enantiomer 'To whom correspondence should be addressed. \*The temperature reported in ref. 4 must be revised.