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2′(3′)-O-L-Aminoacyl derivatives of “bridged” adenine ribonucleosides as substrates for ribosomal peptidyltransferase

✍ Scribed by Prakash Bhuta; Chau-der LiJiří emlička


Book ID
119406447
Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
802 KB
Volume
77
Category
Article
ISSN
0006-291X

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Semisynthesis of 3′(2′)-O-(Aminoacyl)-tR
✍ Zhiyong Cui; Biliang Zhang 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 German ⚖ 217 KB

## Abstract An efficient synthesis of (3′‐terminally) 3′(2′)‐__O__‐aminoacylated pCpA derivatives is described, which could lead to the production of (aminoacyl)‐tRNAs following T4 RNA ligase mediated ligation. The tetrahydrofuranyl (thf) group was used as a permanent protective group for the 2′‐OH