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2.244 PHARMACOKINETICS, PHARMACODYNAMICS AND TOLERABILITY OF OPICAPONE, A NOVEL COMT INHIBITOR, DURING FIRST ADMINISTRATION TO HEALTHY MALE SUBJECTS

✍ Scribed by T. Nunes; J.F. Rocha; R. Pinto; R. Machado; L.C. Wright; A. Falcao; L. Almeida; P. Soares-da-Silva


Book ID
117754937
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
52 KB
Volume
18
Category
Article
ISSN
1353-8020

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Object&z-To assess the tolerability, pharmacokinetics and pharmacodynamics of single oral doses of the novel catechol-0-methyltransferase (COMT) inhibitor tolcapone in healthy volunteers. Metbuuk In this double-blind, placebo-controlled, ascending-single-dose study, doses of 5 to 800 mg tolcapone w