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Pharmacokinetics, pharmacodynamics, and tolerability of single increasing doses of the dipeptidyl peptidase-4 inhibitor alogliptin in healthy male subjects

✍ Scribed by Ronald Christopher; Paul Covington; Michael Davenport; Penny Fleck; Qais A. Mekki; Elisabeth R. Wann; Aziz Karim


Book ID
116372143
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
267 KB
Volume
30
Category
Article
ISSN
0149-2918

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In a double-blind, placebo-controlled, cross-over experiment in 21 healthy male volunteers, aged 19 to 27 y, the pharmacokinetics and tolerance of the new anxiolytic drug alpidem (SL80.0342) and its three major metabolites were studied after single doses of 25, 50, 100 and 200 mg. Plasma concentrati