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Pharmacokinetics, Pharmacodynamics and Tolerability of Opicapone, a Novel Catechol-O-Methyltransferase Inhibitor, in Healthy Subjects

✍ Scribed by Luis Almeida, José Francisco Rocha, Amílcar Falcão, P. Nuno Palma, Ana I. Loureiro, Roberto Pinto, Maria João Bonifácio, Lyndon C. Wright, Teresa Nunes, Patrício Soares-da-Silva


Book ID
118307198
Publisher
Springer International Publishing AG
Year
2012
Tongue
English
Weight
699 KB
Volume
52
Category
Article
ISSN
0312-5963

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Object&z-To assess the tolerability, pharmacokinetics and pharmacodynamics of single oral doses of the novel catechol-0-methyltransferase (COMT) inhibitor tolcapone in healthy volunteers. Metbuuk In this double-blind, placebo-controlled, ascending-single-dose study, doses of 5 to 800 mg tolcapone w