Concise synthesis and biological activit
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Shinobu Honzawa; Yoshitomo Suhara; Ken-ichi Nihei; Nozomi Saito; Seishi Kishimot
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Article
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2003
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Elsevier Science
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English
⚖ 216 KB
We found a concise route to the Trost A-ring precursor enyne for synthesizing 2a-alkylated 1a,25-dihydroxyvitamin D 3 (1) from d-glucose. The enynes were coupled with the 20-epi-CD ring part to study the effect of the double modification of 2asubstitution and 20-epimerization upon biological activit