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22-Alkyl-20- epi -1α,25-dihydroxyvitamin D 3 Compounds of Superagonistic Activity: Syntheses, Biological Activities and Interaction with the Receptor

✍ Scribed by Yamamoto, Keiko; Inaba, Yuka; Yoshimoto, Nobuko; Choi, Mihwa; DeLuca, Hector F.; Yamada, Sachiko


Book ID
126083429
Publisher
American Chemical Society
Year
2007
Tongue
English
Weight
524 KB
Volume
50
Category
Article
ISSN
0022-2623

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We found a concise route to the Trost A-ring precursor enyne for synthesizing 2a-alkylated 1a,25-dihydroxyvitamin D 3 (1) from d-glucose. The enynes were coupled with the 20-epi-CD ring part to study the effect of the double modification of 2asubstitution and 20-epimerization upon biological activit