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Enhanced biological activity of 1α,25-dihydroxy-20-epi-vitamin D3, the C-20 epimer of 1α,25-dihydroxyvitamin D3, is in part due to its metabolism into stable intermediary metabolites with significant biological activity

✍ Scribed by M-L Siu-Caldera; H Sekimoto; S Peleg; C Nguyen; A-M Kissmeyer; L Binderup; A Weiskopf; P Vouros; M.R Uskoković; G.S Reddy

Book ID: 117669247
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 248 KB
Volume: 71
Category: Article
ISSN: 0960-0760
DOI: 10.1016/s0960-0760(99)00130-2

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✍ M-L. Siu-Caldera; D. Sunita Rao; N. Astecker; A. Weiskopf; P. Vouros; K. Konno; 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 254 KB

## Abstract In a recent study, we investigated the metabolism of 1α,25‐dihydroxy‐20‐epi‐vitamin D~3~ (1α,25(OH)~2~‐20‐epi‐D~3~), a potent synthetic vitamin D~3~ analog in the isolated perfused rat kidney and proposed that the enhanced biological activity of 1α,25(OH)~2~‐20‐epi‐D~3~ is in part due t