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Synthesis and biological activity of 22-iodo- and (E)-20(22)-dehydro analogues of 1α,25-dihydroxyvitamin D3

✍ Scribed by Rafal R. Sicinski; Hector F. DeLuca


Book ID
108480772
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
287 KB
Volume
7
Category
Article
ISSN
0968-0896

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Design and synthesis of 1α,25-dihydroxyv
✍ JoséAntonio Martínez-Pérez; Luis Sarandeses; Juan Granja; JoséAntonio Palenzuela 📂 Article 📅 1998 🏛 Elsevier Science 🌐 French ⚖ 221 KB

A series of semi-rigid analogues of the hormone 1 ot,25-dihydroxyvitamin D3 have been designed in order to study the topology required for binding to the hormone receptor (VDR). The new vitamin D3 analogues 2-5 possess a rigid C17--C20 bond and minimal structural modifications on the side-chain with